The Center for Clinical Research

Call 336-283-2732 Directions

Opioid-Induced Constipation (OIC) Clinical Studies in Winston-Salem, NC - Find Out if You Qualify

If you take prescription opioid medication for acute or chronic pain, you may have noticed changes in your digestive health that go beyond the occasional upset stomach. Opioid-Induced Constipation, often referred to as OIC, is a common side effect that happens because opioids slow the movement of the digestive tract. This can make bowel movements less frequent, harder to pass, and generally more uncomfortable.

For many people, OIC doesn't just affect digestion—it can interfere with daily routines, appetite, and overall quality of life. The Center for Clinical Research in Winston-Salem, NC is currently exploring this condition through clinical research, giving eligible individuals the opportunity to learn more about OIC while contributing to studies that may help shape future treatment options.

What Is Opioid-Induced Constipation and What Causes It?

Opioid-Induced Constipation is a gastrointestinal side effect that occurs when opioid medications bind to receptors in the digestive tract, slowing the natural muscle contractions that move stool through the intestines. This slowdown leads to constipation from opioid medication that is often different from typical, occasional constipation—it tends to persist as long as the opioid is being used.

Because opioids are prescribed for a wide range of acute and chronic pain conditions, OIC can affect people of many different backgrounds and health histories throughout the Winston-Salem, NC area.

What Are the Symptoms of OIC?

OIC symptoms can vary from person to person, but they generally center around changes in bowel habits and digestive comfort.

Infrequent Bowel Movements

Going longer than usual between bowel movements is one of the most recognized signs of OIC.

Hard or Dry Stools

Slower digestion often results in stools that are firmer and more difficult to pass.

Difficulty Passing Stools

Many individuals report needing extra time or effort during bowel movements.

Straining During Bowel Movements

This can accompany hard stools and add to overall discomfort.

Abdominal Discomfort

A feeling of pressure, cramping, or general unease in the stomach area.

Bloating

A sensation of fullness or swelling in the abdomen.

Feeling of Incomplete Bowel Emptying

Feeling as though the bowels haven't fully emptied after a bowel movement.

Nausea

Digestive slowdown can sometimes contribute to an upset stomach.

Reduced Appetite

Ongoing digestive discomfort may make eating less appealing.

General Digestive Discomfort

A broad sense that something isn't functioning as it should.

Who Can Participate in Opioid-Induced Constipation Clinical Studies?

Eligibility for OIC clinical studies depends on several factors, and every research study conducted by The Center for Clinical Research has its own specific criteria. That said, there are some general characteristics researchers often look for when considering potential participants.

  • Adults taking opioid medications for pain management
  • Individuals experiencing constipation associated with opioid use
  • Symptoms affecting daily comfort or quality of life
  • Ability to attend scheduled study visits at our Winston-Salem, NC facility
  • Willingness to participate in clinical research
  • Meeting all study-specific eligibility requirements

Eligibility varies by study and can only be confirmed during a formal screening process with our research team.

Doctor consulting with a patient

Why Participate in a Clinical Trial for OIC?

Clinical research plays a vital role in expanding medical understanding of chronic constipation and digestive health related to opioid use. Choosing to participate in a research study is a personal decision, and it can offer several meaningful opportunities.

  • Helping researchers better understand Opioid-Induced Constipation. Your participation contributes directly to the body of medical knowledge on this condition.
  • Supporting the development of future treatment options. Clinical trials are a necessary step in evaluating potential approaches to managing OIC.
  • Access to study-related evaluations. Participants typically receive assessments related to their digestive health throughout the study.
  • Careful monitoring by the clinical research team. Our experienced staff closely oversees each phase of a study.
  • Contributing to future medical research. Your involvement today can help inform care for others in the future.

Participation does not guarantee symptom improvement or any specific outcome, and clinical research is not a substitute for medical treatment.

Participant taking part in a clinical research study

What Happens During a Clinical Research Study?

  • Initial Screening. Most studies begin with a screening visit to determine eligibility based on health history and current symptoms.
  • Scheduled Study Visits. Qualified participants attend study visits where the research team monitors health and gathers study-related information.
  • Experienced Research Team. Our dedicated recruitment staff, regulatory specialists, and experienced study coordinators help guide participants through the process.
  • Guidance Throughout the Process. Every study is explained clearly before participation begins so you understand what to expect.
Participant speaking with a clinical research coordinator

Take the Next Step Toward Understanding OIC

If you're experiencing constipation from opioid medication while managing pain with prescription opioids, you don't have to navigate it without information and support. The Center for Clinical Research invites individuals in Winston-Salem, NC to reach out and learn whether a current Opioid-Induced Constipation clinical study may be a good fit.

Participation is completely voluntary, and every clinical trial has its own eligibility requirements determined through screening. Contact our team today to ask questions, learn more about ongoing research studies, and find out how you might contribute to advancing the understanding of OIC.

Quick Links